醫學研究
高慧茹 Hui-Ju Kao
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現職
新竹馬偕紀念醫院醫學研究科 資深助研究員
聯絡方式
電子信箱: [email protected]
院內分機: 5522-908
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主要學歷
元智大學資訊工程系(生物與醫學資訊) 博士
元智大學生物與醫學資訊 碩士
主要經歷
新竹馬偕紀念醫院醫學研究科 助研究員
香港中文大學瓦謝爾計算生物研究院 博士後研究員
中央研究院化學所 研究助理
執行項目或專長
MAJOR SERVICE
生物資訊學，計算系統生物學，蛋白質功能性分析，資料探勘和機器學習，生物資料庫和線上分析工具開發。
期刊論文
Kai-Yao Huang, Hui-Ju Kao, Tzu-Hsiang Weng, Chia-Hung Chen, Shun-Long Weng, 2022, iDVIP: identification and characterization of viral integrase inhibitory peptides. Briefings in Bioinformatics 2022 Oct 10:bbac406. (SCI, IF:13.994; Q1, 3/79 in BIOCHEMICAL RESEARCH METHODS; 1/57 in MATHEMATICAL & COMPUTATIONAL BIOLOGY.)
Kai-Yao Huang, Yi-Jhan Tseng, Hui-Ju Kao, Chia-Hung Chen, Hsiao-Hsiang Yang, Shun-Long Weng, 2021, Identification of subtypes of anticancer peptides based on sequential features and physicochemical properties. Scientific Reports 2021 Jun 30;11(1):13594. (SCI, IF: 4.379; Q1, 17/73 in MULTIDISCIPLINARY SCIENCES)
Kai-Yao Huang, Fang-Yu Hung, Hui-Ju Kao, Hui-Hsuan Lau, Shun-Long Weng, 2020, iDPGK: characterization and identification of lysine phosphoglycerylation sites based on sequence-based features. BMC Bioinformatics 2020 Dec 9;21(1):568. (SCI, IF: 3.169; Q2, 16/58 in MATHEMATICAL & COMPUTATIONAL BIOLOGY)
Hui-Ju Kao, Van-Nui Nguyen, Kai-Yao Huang, Wen-Chi Chang, Tzong-Yi Lee, 2020 SuccSite: Incorporating Amino Acid Composition and Informative k-spaced Amino Acid Pairs to Identify Protein Succinylation Sites. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):208-219. (SCI, IF: 7.691; Q1, 17/175 in GENETICS & HEREDITY)
Kai-Yao Huang, Tzong-Yi Lee, Hui-Ju Kao, Chen-Tse Ma, Chao-Chun Lee, Tsai-Hsuan Lin, Wen-Chi Chang, and Hsien-Da Huang, 2018, dbPTM in 2019: exploring disease association and cross-talk of post-translational modifications. Nucleic Acids Research 2018 Nov. 10, Vol. 47(D1):D298-D308. (SCI, IF: 16.971; Q1, 8/297 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
Kai-Yao Huang, Hui-Ju Kao, Justin Bo-Kai Hsu, Shun-Long Weng and Tzong-Yi Lee, 2019, Characterization and identification of lysine glutarylation based on intrinsic interdependence between positions in the substrate sites. BMC Bioinformatics, 19(Suppl 13):384. (SCI, IF: 3.169; Q2, 16/58 in MATHEMATICAL & COMPUTATIONAL BIOLOGY)
Hui-Ju Kao+, Shun-Long Weng+, Kai-Yao Huang, Fergie Joanda Kaunang, Justin Bo-Kai Hsu, Chien-Hsun Huang* and Tzong-Yi Lee*, 2017, MDD-Carb: a combinatorial model for the identification of protein carbonylation sites with substrate motifs. BMC Systems Biology, Vol. 11 (Suppl 7), 137. (SCI, IF: 2.048; Q2, 22/59 in MATHEMATICAL & COMPUTATIONAL BIOLOGY)
Shun-Long Weng, Hui-Ju Kao, Chien-Hsun Huang*, Tzong-Yi Lee*, 2017, “MDD-Palm: Identification of protein S-palmitoylation sites with substrate motifs based on maximal dependence decomposition. PLoS ONE, Vol. 12(6): e0179529. (SCI, IF: 3.240; Q2, 26/73 in MULTIDISCIPLINARY SCIENCES)
Shun-Long Weng, Kai-Yao Huang, Fergie Joanda Kaunang, Chien-Hsun Huang, Hui-Ju Kao, Tzu-Hao Chang, Hsin-Yao Wang, Jang-Jih Lu and Tzong-Yi Lee*, 2017, “Investigation and identification of protein carbonylation sites based on position-specific amino acid composition and physicochemical features. BMC Bioinformatics, (SCI, IF: 3.169; Q2, 16/58 in MATHEMATICAL & COMPUTATIONAL BIOLOGY)
Kai-Yao Huang, Min-Gang Su, Hui-Ju Kao, Yun-Chung Hsieh, Jhih-Hua Jhong, Kuang-Hao Cheng, Hsien-Da Huang, Tzong-Yi Lee*, 2016, dbPTM 2016: ten-year anniversary of a resource of post-translational modification of proteins. Nucleic Acids Research 2016 Jan. 4, Vol. 44(D1):D435-D446. (SCI, IF: 16.971; Q1, 8/297 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
Chien-Hsun Huang, Min-Gang Su, Hui-Ju Kao, Jhih-Hua Jhong, Shun-Long Weng and Tzong-Yi Lee*, 2016, UbiSite: incorporating two-layered machinelearning method with substrate motifs topredict ubiquitin-conjugation site on lysines. BMC Systems Biology, Vol. 10 (Suppl 1):6. (SCI, IF: 2.048; Q2, 22/59 in MATHEMATICAL & COMPUTATIONAL BIOLOGY)
Hui-Ju Kao+, Chien-Hsun Huang+ (+ joint first authorship), Neil Arvin Bretana, Cheng-Tsung Lu, Kai-Yao Huang, Shun-Long Weng*, and Tzong-Yi Lee*, 2015, A two-layered machine learning method to identify protein O-GlcNAcylation sites with O-GlcNAc transferase substrate motifs. BMC Bioinformatics, Vol. 16, Suppl 18, S10. (SCI, IF: 3.169; Q2, 16/58 in MATHEMATICAL & COMPUTATIONAL BIOLOGY)
Hsin-Yi Wu, Cheng-Tsung Lu, Hui-Ju Kao, Yi-Ju chen, Tzong-Yi Lee* and Yu-Ju Chen*, 2014, Characterization and identification of protein O-GlcNAcylation sites with substrate specificity. BMC Bioinformatics, Vol. 15 (Suppl 16), S1. (SCI, IF: 3.169; Q2, 16/58 in MATHEMATICAL & COMPUTATIONAL BIOLOGY)
Min-Gang Su, Kai-Yao Huang, Cheng-Tsung Lu, Hui-Ju Kao, Ya-Han Chang and Tzong-Yi Lee*, 2014, topPTM: a new module of dbPTM for identifying functional post-translational modifications in transmembrane proteins. Nucleic Acids Research, Vol. 42 (D1): D537-D545. (SCI, IF: 16.971; Q1, 8/297 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
研討會論文
Kai-Yao Huang, Hui-Ju Kao, Justin Bo-Kai Hsu, Shun-Long Weng and Tzong-Yi Lee (2018, Sept) Characterization and identification of lysine glutarylation based on intrinsic interdependence between positions in the substrate sites. The 17th International Conference on Bioinformatics (InCoB 2018).
Chien-Hsun Huang, Min-Gang Su, Hui-Ju Kao, Jhih-Hua Jhong, Shun-Long Weng and Tzong-Yi Lee, 2016, Incorporating two-layered machine learning method with substrate motifs to predict ubiquitin-conjugation site on lysines. The Fourteenth Asia Pacific Bioinformatics Conference (APBC 2016), 11-13 January 2016, San Francisco Bay Area, United States.
Hui-Ju Kao (Oral speaker), Chien-Hsun Huang, Neil Arvin Bretana, Cheng-Tsung Lu, Kai-Yao Huang, Shun-Long Weng, and Tzong-Yi Lee A two-layered machine learning method to identify protein O-GlcNAcylation sites with O-GlcNAc transferase substrate motifs. 14th International Conference on Bioinformatics (GIW/InCoB 2015), 9 - 11 September, Odaiba, Tokyo, Japan.
Hui-Ju Kao (Oral speaker) and Tzong-Yi Lee, Characterization and Identification of Protein O-linked Glycosylation Sites based on Glycosyltransferase Substrate Specificities. The Thirteenth Asia Pacific Bioinformatics Conference (APBC 2015), 21-23 January 2015, HsinChu, Taiwan. (Best Poster Presentation Award)
Hsin-Yi Wu, Cheng-Tsung Lu, Hui-Ju Kao, Yi-Ju Chen, Tzong-Yi Lee and Yu-Ju chen, Characterization and identification of protein O-GlcNAcylation sites with substrate specificity. 13th International Conference on Bioinformatics (InCoB 2014), 31st July - 2nd August, Sydney, New South Wales, Australia.
Kai-Yao Huang, Ming-Gang Su, Hui-Ju Kao, Ya-Han Chang, Tzong-Yi Lee, PhosNet: A Web Tool to Reconstruct the Protein Kinase–substrate Phosphorylattion Network Integrating Protein-protein Interaction and Biological Pathway Data. The 3rd International Congress on Natural Sciences and Engineering (ICNSE 2014), 7 - 9 May, 2014, Koyto, Japan.